Disruption is the act of changing cultural practices, and introducing new practices, that involve a greater emphasis on social responsibility and sustainability. I will discuss several facets of disruption as it pertains to entrepreneurship. First, I will provide an overview of disruption itself and why it matters, along with case studies from the entrepreneurial world. Secondly, I will address what many consider to be the primary obstacle to disruption, and to entrepreneurship, which is failure, or more precisely, the fear of failure, and strategies that others have used in the past to remove failure as an obstacle to success. I will also discuss how disruption can take place anywhere, and in any industry, toward the improvement of the human condition. Lastly, I will discuss characteristics that comprise the disruptive leader, along with common challenges such leaders face and the outcomes to which they strive.