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Association for Behavior Analysis International

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Ninth International Conference; Paris, France; 2017

Event Details

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Paper Session #1
CANCELED: Epigenetic Mechanisms and the Effects of Postnatal Maternal Care in the Development of Offspring's Stress Vulnerability
Tuesday, November 14, 2017
2:00 PM–2:20 PM
Studio DE, Niveau 2
Area: DEV
Instruction Level: Intermediate
Chair: Grazielle Noro (Universidade Estadual de Londrina)
CANCELED: Epigenetic Mechanisms and the Effects of Postnatal Maternal Care in the Development of Offspring's Stress Vulnerability
Domain: Basic Research
GRAZIELLE NORO (Universidade Estadual de Londrina), Márcia Cristina Gon Caserta (Universidade Estadual de Londrina)
Abstract: Early life experiences have been consistently related to alterations in the genetic expression through epigenetic mechanisms such as DNA methylation or DNA histone modification. The present study aims to investigate the effects of the maternal care on the development of the stress vulnerability on the infant through epigenetic alterations and its relation as well as the relation of other studies on neurodevelopment, to Behavior Analysis. Dam's behavioral responses of licking, grooming and arched-back nursing their offspring have been related to epigenetic mechanisms that regulate stress reactivity through alterations in the HPA axis function. Offspring of high rates LG-ABN dams showed low vulnerability to stress because of the hypoactivation of the HPA axis mediated by low rates of corticotrophin hormone (CRF), high rates of novelty seeking, low rates of DNA methylation and high rates of DNA deacethylation of glucocorticoids receptor gene promoters as well as GABA and benzodiazepinic receptor gene promoters. The epigenetic mechanisms that operate on the offspring show the importance of post-natal maternal care and also relate to B. F. Skinner's statement about the possible physiological alterations related to the operant conditioning. It also signalizes to effective intervention based on the plasticity of the epigenome formation.
 
 
 

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