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| Recent investigations in human behavioral pharmacology |
| Sunday, May 30, 2004 |
| 10:00 AM–10:50 AM |
| Beacon E |
| Area: BPH |
| Chair: John M. Roll (UCLA) |
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| GHB: Basic Human Behavioral Pharmacology |
| Domain: Applied Research |
| JOY ELIZABETH CHUDZYNSKI (UCLA), John M. Roll (UCLA), Christina Harding (UCLA) |
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| Abstract: GHB is an increasingly popular "club drug". Its use has been associated with a number of adverse events, up to and including death. It has also been implicated in the commission of several sexual assaults. To date, there have not been well-controlled studies examining the effects of GHB in regular, recreational users. The proposed talk will present data from an intensive inpatient study in which participants receive several doses of of GHB and rate the putative reinforcing efficacy of each with a multiple choice procedure in which they equate the different doses of GHB with different monetary amounts. Subsequently, participants are given a chance to actually self-admininister the dose of GHB they rated as most reinforcing with the multiple choice procedure. Results from the initial three participants to complete the protocol suggest that the reinforcing efficacy of GHB increases in a dose-dependent fashion. |
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| Modulation of Human Methamphetamine Self-Administration by the Provision of an Alternative Source of Reinforcement |
| Domain: Applied Research |
| JOHN M. ROLL (UCLA), Tom Newton (UCLA), Joy Elizabeth Chudzynski (UCLA), Christina Harding (UCLA) |
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| Abstract: Methamphetamine abuse is a pernicious problem in much of the world. We have been investigating potential treatments for this disorder. The ongoing study to be discussed in this presentaton is a laboratory model in which particpants make repeated choices between self-adminsitering methamphetamine or choosing monteray alternatives. The magnitude of the monetary reinforcers varies between sessions while the dose of methamphetamine remains constant. Preliminary results suggest that methamphetamine self-adminsitration is sensitive to the presence of alternative sources of reinforcement in this paradigm. With half of the scheduled particpants having completed their participation it appears that the proclivity to adminsiter methamphetamine decreases in an orderly fashion as the magnitude of the alternative source of reinforcement increases. These findings will be discussed in terms of basic science applications and potential clinical utility. |
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