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The use of cannabis (marijuana) for medical and non-medical purposes is expanding worldwide and now includes legal retail outlets for purchasing cannabis products in many areas. Retail cannabis products are varied with respect to dose and intended route of administration, yet the preponderance of scientific data is limited to analysis of the effects of smoked cannabis. This presentation will summarize data from a series of controlled human laboratory studies evaluating the dose effects of oral, smoked, and vaporized cannabis in healthy, non-tolerant individuals. Outcome measures to be described include subjective ratings of drug effects, cardiovascular measures, cannabinoid quantitation in biological fluid, and performance on psychomotor, memory, and divided attention tasks. Implications of the study findings will be discussed with respect to regulation of medical and non-medical cannabis products, drug testing, and education.
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