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B. F. Skinner argued that neurobiology was not necessary to explain operant behavior. However, some of his most publicized conjectures could only be tested using neurobiological methods. For instance, 1959, in what may be one of the most decisive debates in modern psychology (or cognitive neuroscience), Noam Chomsky gutted Skinner's claims that human language were acquired via operant processes. By understanding and comparing the neurobiological mechanisms of operant learning in different animals, we now are beginning to accumulate evidence that Skinner was at least partially correct: there is a dedicated, evolutionarily conserved biochemical mechanism underlying behavioral learning which does not seem to be involved in the other forms of learning tested so far. This mechanism is also involved in acquiring at least the speech component of language, articulation. Coincidentally, such experiments also solved a technical problem first formulated by Skinner in 1935. Behavioral experiments were performed ~80% statistical power and have been internally replicated before publication. These replications often included different genetic modifications targeting the same biological structure, providing converging evidence for any given effect.